منابع مشابه
Determination of chemical and radiochemical purity of [14C] clozapine by high performance liquid chromatography and liquid scintillation [Persian]
Introduction: The mechanism of action and metabolism of clozapine, a complex drug used in psychopharmacology, is not completely understood. The effects of this compound in human body are related to some interactions with serotonin and dopamine neurotransmitter receptors. To further elucidate the mechanism of action and to support ongoing drug metabolism studies, [14C] clozapine with suita...
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The determination of absolute purity by DSC has been an accepted technique since the mid 1960s. One source of error in the purity method, that has limited its applicability and accuracy, is uncorrected thermal lag. New DSC instrumentation incorporates these corrections directly into the heat flow signal. This superior approach leads to improved peak resolution and to more accurate purity analys...
متن کاملPreparation and purity determination of radiolabeled taxol and evaluation of its absorption in murine melanoma
Aim and Background:Taxol is a known substrate for P-glycoprotein, which induces drug resistance to cancerous cells. Therefore radiolabeled taxol can be a suitable probe for imaging of the P-glycoprotein transport ability to determine drug resistance. The aim of this study was to provide labeled taxol and to determine the rate of uptake in the tumor to evaluate the location of the tumor and the ...
متن کاملImmunological and chemical purity of papain-solubilized HL-A antigens.
Three preparations of purified papain-solublized HL-A antigens have been radiolabeled by reductive methylation using formaldehyde and potassium boro[3H]hydride, and their reaction with specific HL-A antisera has been investigated. Greater than 99 percent of the radioactivity in the [3H]HL-A2 preparation could be complexed with several HL-A2 antisera, but not with specificity controls. The other...
متن کاملPurity determination of gynalgin bactericidal tablets with HPLC method.
The study was aimed at developing a simple HPLC method for the determination of the content of impurities in Gynalgin, a two-component preparation. A satisfactory separation was performed on 250 x 4.6 mm Symmetry C8 column in a gradient elution system: mobile phase A--acetonitrile/buffer, pH 5.5 in 10:90, v/v proportion, and mobile phase B--acetonitrile/buffer, pH 5.5 in 75:25 v/v proportion. T...
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ژورنال
عنوان ژورنال: Nature
سال: 1949
ISSN: 0028-0836,1476-4687
DOI: 10.1038/164503a0